Curcumin nanoliposomes mitigate wound tissue inflammatory response caused by tooth extraction

Curcumin is a plant-derived compound with polypharmacological properties that are hampered by its poor solubility, fast degradation, etc. Wound closure complications follow tooth extraction numerous, and relatively frequently additional treatment needed to prevent unwanted process chronification. The present study aims compare the effects of free nanoliposome-encapsulated curcumin on wound closure. experiments were performed Wistar rats where both forms applied topically for seven days. Changes in tissue oxidative stress (malondialdehyde oxidized proteins concentrations, catalase activity) inflammation (nitric oxide levels myeloperoxidase related parameters studied three days following extraction. Also, extent pathohistological changes osteopontin immunohistochemical expression studied. obtained results indicate an increase inflammation-related samples at 3-and 7-day time points. Additionally, we found diminished inflammatory response expression, while same it caused faster granulation maturation. encapsulation nanoliposomes proved be better improving healing than curcumin, giving this formulation potential pharmaceutical industry.